The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.
Farsi Z, Nicolella A, Simmons SK, Aryal S, Shepard N, Brenner K, Lin S, Herzog L, Moran SP, Stalnaker KJ, Shin W, Gazestani V, Song BJ, Bonanno K, Keshishian H, Carr SA, Pan JQ, Macosko EZ, Datta SR, Dejanovic B, Kim E, Levin JZ, Sheng M. Neuron. 2023 Nov 1;111(21):3378-3396.e9.
Children’s cognitive performance and suicide risk through middle adulthood.
Vidal-Ribas P, Govender T, Yu J, Sundaram R, Perlis RH, Gilman SE. J Child Psychol Psychiatry. 2023 Oct;64(10):1480-1491. doi: 10.1111/jcpp.13841.
Brief cognitive-behavioral treatment for avoidant/restrictive food intake disorder in the context of functional dyspepsia: Study protocol for a feasibility randomized controlled trial.
Burton Murray H, Ljótsson B, Healy B, Van Oudenhove L, Williams JS, Keefer L, Lawson EA, Kuo B, Thomas JJ. Contemp Clin Trials. 2023 Sep 16;134:107336.
Community Mobility and Depressive Symptoms During the COVID-19 Pandemic in the United States.
Perlis RH, Lunz Trujillo K, Safarpour A, Quintana A, Simonson MD, Perlis J, Santillana M, Ognyanova K, Baum MA, Druckman JN, Lazer D. JAMA Netw Open. 2023 Sep 5;6(9):e2334945.
An Alternative Proposal for Teaching Medical Students About Psychiatry: Consultation-Liaison Psychiatry Rotations That Consult to Medical and Surgical Services.
Rustad JK, Schlozman SC, Chen J, Stern TA. Acad Psychiatry. 2023 Aug 8. doi: 10.1007/s40596-023-01834-1.
Diagnosing major depressive disorder and substance use disorder using the electronic health record: A preliminary validation study.
Rao V, Lanni S, Yule AM, DiSalvo M, Stone M, Berger AF, Wilens TE. J Mood Anxiety Disord. 2023 Aug;2:100007.
A 50-state survey study of thoughts of suicide and social isolation among older adults in the United States.
Solomonov N, Green J, Quintana A, Lin J, Ognyanova K, Santillana M, Druckman JN, Baum MA, Lazer D, Gunning FM, Perlis RH. J Affect Disord. 2023 Aug 1;334:43-49. doi: 10.1016/j.jad.2023.04.038.
Do Tobacco Treatment Trials Address Disparities in Smoking Outcomes Among Black and Hispanic Cancer Patients? A Systematic Review of Smoking Cessation Interventions for Black and Hispanic Patients Diagnosed with Cancer.
Perez GK, Rabin JT, Tandon M, Strauss NM, Irwin K, Philpotts L, Ostroff J, Park ER. J Racial Ethn Health Disparities. 2023 Jul 19.
Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.
Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J. Mol Psychiatry. 2023 Jul 4. doi: 10.1038/s41380-023-02152-6.
An atlas of healthy and injured cell states and niches in the human kidney.
Lake BB, Menon R, Winfree S, Hu Q, Melo Ferreira R, Kalhor K, Barwinska D, Otto EA, Ferkowicz M, Diep D, Plongthongkum N, Knoten A, Urata S, Mariani LH, Naik AS, Eddy S, Zhang B, Wu Y, Salamon D, Williams JC, Wang X, Balderrama KS, Hoover PJ, Murray E, Marshall JL, Noel T, Vijayan A, Hartman A, Chen F, Waikar SS, Rosas SE, Wilson FP, Palevsky PM, Kiryluk K, Sedor JR, Toto RD, Parikh CR, Kim EH, Satija R, Greka A, Macosko EZ, Kharchenko PV, Gaut JP, Hodgin JB; KPMP Consortium; Eadon MT, Dagher PC, El-Achkar TM, Zhang K, Kretzler M, Jain S. Nature. 2023 Jul;619(7970):585-594.
Association of BCG Vaccine Treatment With Death and Dementia in Patients With Non-Muscle-Invasive Bladder Cancer.
Weinberg MS, Zafar A, Magdamo C, Chung SY, Chou WH, Nayan M, Deodhar M, Frendl DM, Feldman AS, Faustman DL, Arnold SE, Vakulenko-Lagun B, Das S. JAMA Netw Open. 2023 May 1;6(5):e2314336.
A 10-Year Follow-up Survey of Psychiatry Resident Education in Consultation-Liaison Psychiatry.
Beach SR, Ernst CL, Lavakumar M, Greenstein SP, Fipps DC, Soeprono TM, Heinrich TW, Schwartz AC. J Acad Consult Liaison Psychiatry. 2023 May-Jun;64(3):199-208.
Does the association between Herpes Simplex 2 infection and depressive symptoms vary among different sexual minority statuses and sex groups? Findings from a nationally representative sample.
Lu J, Liang J, Yang J, Mischoulon D, Nyer M. J Affect Disord. 2023 Apr 14;327:226-229.
Classifying Firearm Injury Using EHR Data-Finding the Phenotype by Reading the Notes.
Perlis RH. JAMA Netw Open. 2023 Apr 3;6(4):e235781.
Association Between Ghrelin and Body Weight Trajectory in Individuals With Anorexia Nervosa.
Kim YR, Lauze MS, Slattery M, Perlis RH, Holsen LM, Breithaupt L, Stern CM, Fava M, Thomas JJ, Lawson EA, Misra M, Eddy KT. JAMA Netw Open. 2023 Mar 1;6(3):e234625.
Associations Among Loneliness, Purpose in Life and Subjective Cognitive Decline in Ethnoracially Diverse Older Adults Living in the United States.
Pluim CF, Anzai JAU, Martinez JE, Munera D, Garza-Naveda AP, Vila-Castelar C, Guzmán-Vélez E, Ramirez-Gomez L, Bustin J, Serrano CM, Babulal GM, Okada de Oliveira M, Quiroz YT. J Appl Gerontol. 2023 Mar;42(3):376-386.
The descriptive analysis of depressive symptoms and White Blood Cell (WBC) count between the sexual minorities and heterosexual identifying individuals in a nationally representative sample: 2005-2014.
Lu J, Yang J, Liang J, Mischoulon D, Nyer M. BMC Public Health. 2023 Feb 9;23(1):294.
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses.
Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven BM, Subtelny AO, Zlatev DV, Wszolek MW, Salari K, Murray E, Chen F, Macosko EZ, Wu CL, Scadden DT, Dahl DM, Baryawno N, Saylor PJ, Kharchenko PV, Sykes DB. Nat Commun. 2023 Feb 7;14(1):663.
Association of Post-COVID-19 Condition Symptoms and Employment Status.
Perlis RH, Lunz Trujillo K, Safarpour A, Santillana M, Ognyanova K, Druckman J, Lazer D. JAMA Netw Open. 2023 Feb 1;6(2):e2256152.
Distinct and shared white matter abnormalities when ADHD is comorbid with ASD: A preliminary diffusion tensor imaging study.
Hung Y, Dallenbach NT, Green A, Gaillard S, Capella J, Hoskova B, Vater CH, Cooper E, Rudberg N, Takahashi A, Gabrieli JDE, Joshi G. Psychiatry Res. 2023 Feb;320:115039.
