The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
Trinh NT, Talukder F, Nagendra A, Ali AM, Emmerich A, Chow L, Jenkins JH, Okereke OI. Psychiatr Serv. 2024 Apr 1;75(4):391-394.
Advancing Methodological Rigor for Psychosocial Aspects of Neuropalliative Care Interventions.
Plys E, Grunberg VA, Vranceanu AM. J Palliat Care. 2024 Apr;39(2):92-96.
Identification of patient subgroups who benefit from a behavioral intervention to improve adjuvant endocrine therapy adherence: a randomized-controlled trial.
Walsh EA, Post K, Massad K, Horick N, Antoni MH, Penedo FJ, Safren SA, Partridge AH, Peppercorn J, Park ER, Temel JS, Greer JA, Jacobs JM. Breast Cancer Res Treat. 2024 Apr;204(3):547-559.
Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.
Sheridan SD, Horng JE, Yeh H, McCrea L, Wang J, Fu T, Perlis RH. Biol Psychiatry. 2024 Apr 1;95(7):676-686.
Use of Machine Learning to Optimize Referral for Early Palliative Care: Are Prognostic Predictions Enough?
Weissman GE, Greer JA, Temel JS. J Clin Oncol. 2024 Mar 15:JCO2400024.
Effects of Prenatal Exposure to Second-Generation Antipsychotics on Development and Behavior Among Preschool-Aged Children: Preliminary Results From the National Pregnancy Registry for Psychiatric Medications.
Swetlik C, Cohen LS, Kobylski LA, Sojka ET, Killenberg PC, Freeman MP, Viguera AC. J Clin Psychiatry. 2024 Mar 13;85(1):23m14965.
Clinical decision support for bipolar depression using large language models.
Perlis RH, Goldberg JF, Ostacher MJ, Schneck CD. Neuropsychopharmacology. 2024 Mar 13.
Clinical characteristics among sexual minority and heterosexual women with body dysmorphic disorder.
Wolfe EC, Snorrason I, Laky ZE, Miyares P, Klare D, Fang A, Summers B, Phillips KA, Wilhelm S, Greenberg JL. Body Image. 2024 Mar 11;49:101687.
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models.
Tai DJC, Razaz P, Erdin S, Gao D, Wang J, Nuttle X, de Esch CE, Collins RL, Currall BB, O’Keefe K, Burt ND, Yadav R, Wang L, Mohajeri K, Aneichyk T, Ragavendran A, Stortchevoi A, Morini E, Ma W, Lucente D, Hastie A, Kelleher RJ, Perlis RH, Talkowski ME, Gusella JF. Am J Hum Genet. 2024 Mar 7;111(3):619.
Emotional distress, social support, and functional dependence predict readiness for hospital discharge in a prospective sample of cognitively intact cardiac arrest survivors.
Presciutti AM, Enkhtsetseg N, Flickinger KL, Coppler PJ, Ratay C, Doshi AA, Perman SM, Vranceanu AM, Elmer J. Resuscitation. 2024 Mar 6;198:110166.
Protocol for multi-site randomized trial of inpatient palliative care for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation.
Yang D, Newcomb R, Kavanaugh AR, Khalil D, Greer JA, Chen YB, DeFilipp Z, Temel J, Lee SJ, LeBlanc TW, El-Jawahri A. Contemp Clin Trials. 2024 Mar;138:107460.
The lived experiences of individuals with postpartum psychosis: A qualitative analysis.
Vanderkruik R, Kobylski LA, Dunk MM, Arakelian MH, Gaw ML, Dineen H, Kanamori M, Freeman MP, Cohen LS. J Affect Disord. 2024 Mar 1;348:367-377.
Apolipoprotein E and Its Association With Cognitive Change and Modification of Treatment Effects of Vitamin D3 and Omega-3s on Cognitive Change: Results From the In-Clinic Subset of a Randomized Clinical Trial.
Vyas CM, Kang JH, Mischoulon D, Cook NR, Reynolds Iii CF, Chang G, Mora S, De Vivo I, Manson JE, Okereke OI. J Gerontol A Biol Sci Med Sci. 2024 Mar 1;79(3):glad260.
Concurrent factors associated with adherence to adjuvant endocrine therapy among women with non-metastatic breast cancer.
Walsh EA, Walsh LE, Hernand M, Horick N, Antoni MH, Temel JS, Greer JA, Jacobs JM.
J Cancer Surviv. 2024 Feb 24.
Symptoms of Catatonia Observed in Down Syndrome Regressive Disorder: A Retrospective Analysis.
Smith JR, Baldwin I, Lim S, Luccarelli J. J Autism Dev Disord. 2024 Feb 22.
HIV, multimorbidity, and health-related quality of life in rural KwaZulu-Natal, South Africa: A population-based study.
Stanton AM, Boyd RL, O’Cleirigh C, Olivier S, Dolotina B, Gunda R, Koole O, Gareta D, Modise TH, Reynolds Z, Khoza T, Herbst K, Ndung’u T, Hanekom WA, Wong EB, Pillay D, Siedner MJ; Vukuzazi Study Team. PLoS One. 2024 Feb 21;19(2):e0293963.
The salience of structural barriers and behavioral health problems to ART adherence in people receiving HIV primary care in South Africa.
Safren SA, Lee JS, Andersen LS, Stanton AM, Kagee A, Kirakosian N, O’Cleirigh C, Joska JA. AIDS Care. 2024 Feb 15:1-7.
Financial burden following adult liver transplantation is common and associated with adverse recipient outcomes.
Ufere NN, Serper M, Kaplan A, Horick N, Indriolo T, Li L, Satapathy N, Donlan J, Castano Jimenez JC, Lago-Hernandez C, Lieber S, Gonzalez C, Keegan E, Schoener K, Bethea E, Dageforde LA, Yeh H, El-Jawahri A, Park ER, Vodkin I, Schonfeld E, Nipp R, Desai A, Lai JC. Liver Transpl. 2024 Feb 15.
Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection.
Shook LL, Castro VM, Herzberg EM, Fourman LT, Kaimal AJ, Perlis RH, Edlow AG. Obesity (Silver Spring). 2024 Feb 13.
Timing and duration of dog walking and dog owner’s chronotype in relation to incident depression risk among middle to older-aged female nurses.
Żebrowska M, Strohmaier S, Westgarth C, Huttenhower C, Eliassen HA, Haghayegh S, Huang T, Laden F, Hart J, Rosner B, Kawachi I, Chavarro JE, Okereke OI, Schernhammer ES. PLoS One. 2024 Jan 31;19(1):e0296922.
Use of ECT for Children With and Without Catatonia: A Single-Site Retrospective Analysis.
Smith JR, Baldwin I, Termini KA, McGonigle T, Vandekar S, Luccarelli J.
J ECT. 2024 Jan 25. doi: 10.1097/YCT.0000000000000993. Online ahead of print.
PMID: 38265759
Managing Symptom Distress: Key Factors for Patients on Adjuvant Endocrine Therapy for Breast Cancer.
Post KE, Ahmad Z, Jankauskaite G, Centracchio J, Oswald L, Horick N, Park ER, Temel JS, Greer JA, Jacobs J. J Pain Symptom Manage. 2024 Jan;67(1):88-97.
Risk Stratification of QTc Prolongation in Critically Ill Patients Receiving Antipsychotics for the Management of Delirium Symptoms.
Sadlonova M, Beach SR, Funk MC, Rosen JH, Ramirez Gamero AF, Karlson RA, Huffman JC, Celano CM. J Intensive Care Med. 2023 Dec 21:8850666231222470.
The Diagnosis of Malingering in General Hospitals in the United States: A Retrospective Analysis of the National Inpatient Sample.
Punko D, Luccarelli J, Bains A, MacLean R, Taylor JB, Kontos N, Smith FA, Beach SR. Gen Hosp Psychiatry. 2023 Nov-Dec;85:133-138.
Emulating a Target Trial of Dynamic Treatment Strategies for Major Depressive Disorder Using Data From the STAR∗D Randomized Trial.
Szmulewicz AG, Wanis KN, Perlis RH, Hernández-Díaz S, Öngür D, Hernán MA. Biol Psychiatry. 2023 Jun 15;93(12):1127-1136.
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.
Rapino F, Natoli T, Limone F, O’Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O’Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL. Stem Cell Reports. 2023 Jan 10;18(1):237-253.
