The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities.
Venner E, Patterson K, Kalra D, Wheeler MM, Chen YJ, Kalla SE, Yuan B, Karnes JH, Walker K, Smith JD, McGee S, Radhakrishnan A, Haddad A, Empey PE, Wang Q, Lichtenstein L, Toledo D, Jarvik G, Musick A, Gibbs RA; All of Us Research Program Investigators. Commun Biol. 2024 Feb 19;7(1):174.
Officer-Involved Killings of Unarmed Black People and Racial Disparities in Sleep Health.
Venkataramani AS, Bair EF, Bor J, Jackson CL, Kawachi I, Lee J, Papachristos A, Tsai AC. JAMA Intern Med. 2024 Feb 5:e238003.
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models.
Tai DJC, Razaz P, Erdin S, Gao D, Wang J, Nuttle X, de Esch CE, Collins RL, Currall BB, O’Keefe K, Burt ND, Yadav R, Wang L, Mohajeri K, Aneichyk T, Ragavendran A, Stortchevoi A, Morini E, Ma W, Lucente D, Hastie A, Kelleher RJ, Perlis RH, Talkowski ME, Gusella JF. Am J Hum Genet. 2024 Mar 7;111(3):619.
Comparing Pharmacotherapies for ADHD in Adults: Evidence From Outcome-Focused Analysis of Food and Drug Administration Drug Label Registration Trials.
Surman CBH, Walsh DM, Bond JB. J Atten Disord. 2024 Mar;28(5):800-809.
Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection.
Shook LL, Castro VM, Herzberg EM, Fourman LT, Kaimal AJ, Perlis RH, Edlow AG. Obesity (Silver Spring). 2024 Feb 13.
HIV, Social Networks, and Loneliness among Older Adults in Uganda.
Quach LT, Ritchie CS, Reynolds Z, Paul R, Seeley J, Tong Y, Hoeppner S, Okello S, Nakasujja N, Olivieri-Mui B, Saylor D, Greene M, Asiimwe S, Tindimwebwa E, Atwiine F, Sentongo R, Siedner MJ, Tsai AC. AIDS Behav. 2024 Feb;28(2):695-704.
A Cost Model for a Low-Threshold Clinic Treating Opioid Use Disorder.
Wakeman SE, Powell E, Shehab S, Herman G, Kehoe L, Kaplan RS. J Behav Health Serv Res. 2024 Jan;51(1):22-30.
Clinical decision support for bipolar depression using large language models.
Perlis RH, Goldberg JF, Ostacher MJ, Schneck CD. Neuropsychopharmacology. 2024 Mar 13.
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.
Ou AH, Rosenthal SB, Adli M, Akiyama K, et al. Transl Psychiatry. 2024 Feb 23;14(1):109.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S; PGC-MDD Working Group; China Kadoorie Biobank Collaborative Group; 23andMe Research Team; Genes and Health Research Team; BioBank Japan Project; Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Nat Genet. 2024 Feb;56(2):222-233.
Lower region-specific gray matter volume in females with atypical anorexia nervosa and anorexia nervosa.
Lyall AE, Breithaupt L, Ji C, Haidar A, Kotler E, Becker KR, Plessow F, Slattery M, Thomas JJ, Holsen LM, Misra M, Eddy KT, Lawson EA. Int J Eat Disord. 2024 Feb 17. doi: 10.1002/eat.24168. Online ahead of print.
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.
Lennon NJ, Kottyan LC, Kachulis C, Abul-Husn NS, Arias J, Belbin G, Below JE, Berndt SI, Chung WK, Cimino JJ, Clayton EW, Connolly JJ, Crosslin DR, Dikilitas O, Velez Edwards DR, Feng Q, Fisher M, Freimuth RR, Ge T; GIANT Consortium; All of Us Research Program; Glessner JT, Gordon AS, Patterson C, Hakonarson H, Harden M, Harr M, Hirschhorn JN, Hoggart C, Hsu L, Irvin MR, Jarvik GP, Karlson EW, Khan A, Khera A, Kiryluk K, Kullo I, Larkin K, Limdi N, Linder JE, Loos RJF, Luo Y, Malolepsza E, Manolio TA, Martin LJ, McCarthy L, McNally EM, Meigs JB, Mersha TB, Mosley JD, Musick A, Namjou B, Pai N, Pesce LL, Peters U, Peterson JF, Prows CA, Puckelwartz MJ, Rehm HL, Roden DM, Rosenthal EA, Rowley R, Sawicki KT, Schaid DJ, Smit RAJ, Smith JL, Smoller JW, Thomas M, Tiwari H, Toledo DM, Vaitinadin NS, Veenstra D, Walunas TL, Wang Z, Wei WQ, Weng C, Wiesner GL, Yin X, Kenny EE. Nat Med. 2024 Feb;30(2):480-487.
Performance of a Maternal Risk Stratification System for Predicting Low Apgar Scores.
Kishkovich TP, James KE, McCoy TH, Perlis RH, Kaimal AJ, Clapp MA. Am J Perinatol. 2024 Mar 1.
Cognitive Symptoms of Post-COVID-19 Condition and Daily Functioning.
Jaywant A, Gunning FM, Oberlin LE, Santillana M, Ognyanova K, Druckman JN, Baum MA, Lazer D, Perlis RH. JAMA Netw Open. 2024 Feb 5;7(2):e2356098.
Polygenic Risk for Type 2 Diabetes in African Americans.
Irvin MR, Ge T, Patki A, Srinivasasainagendra V, Armstrong ND, Davis B, Jones AC, Perez E, Stalbow L, Lebo M, Kenny E, Loos RJF, Ng MCY, Smoller JW, Meigs JB, Lange LA, Karlson EW, Limdi NA, Tiwari HK. Diabetes. 2024 Mar 12:db230232.
Genetic sex validation for sample tracking in next-generation sequencing clinical testing.
Hu J, Korchina V, Zouk H, Harden MV, Murdock D, Macbeth A, Harrison SM, Lennon N, Kovar C, Balasubramanian A, Zhang L, Chandanavelli G, Pasham D, Rowley R, Wiley K, Smith ME, Gordon A, Jarvik GP, Sleiman P, Kelly MA, Bland HT, Murugan M, Venner E, Boerwinkle E; eMERGE III consortium; Prows C, Mahanta L, Rehm HL, Gibbs RA, Muzny DM. BMC Res Notes. 2024 Mar 3;17(1):62.
Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation.
Ge R, Yu Y, Qi YX, Fan YN, Chen S, Gao C, Haas SS, New F, Boomsma DI, Brodaty H, Brouwer RM, Buckner R, Caseras X, Crivello F, Crone EA, Erk S, Fisher SE, Franke B, Glahn DC, Dannlowski U, Grotegerd D, Gruber O, Hulshoff Pol HE, Schumann G, Tamnes CK, Walter H, Wierenga LM, Jahanshad N, Thompson PM, Frangou S; ENIGMA Lifespan Working Group. Lancet Digit Health. 2024 Mar;6(3):e211-e221.
The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research.
Bianchi DW, Brennan PF, Chiang MF, Criswell LA, D’Souza RN, Gibbons GH, Gilman JK, Gordon JA, Green ED, Gregurick S, Hodes RJ, Kilmarx PH, Koob GF, Koroshetz WJ, Langevin HM, Lorsch JR, Marrazzo JM, Pérez-Stable EJ, Rathmell WK, Rodgers GP, Rutter JL, Simoni JM, Tromberg BJ, Tucci DL, Volkow ND, Woychik R, Zenk SN, Kozlowski E, Peterson RS, Ginsburg GS, Denny JC. Nat Med. 2024 Feb;30(2):330-333.
