The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
Hypertension differentially impacts cognition in men and women in early midlife.
Shields HL, Konishi K, Aroner S, Aizley H, Remington A, Lee H, Buka S, Goldstein JM. J Neuropsychol. 2023 Mar;17(1):146-160.
Clinical response to EPA supplementation in patients with major depressive disorder is associated with higher plasma concentrations of pro-resolving lipid mediators.
Lamon-Fava S, Liu M, Dunlop BW, Kinkead B, Schettler PJ, Felger JC, Ziegler TR, Fava M, Mischoulon D, Rapaport MH. Neuropsychopharmacology. 2023 May;48(6):929-935.
Cannabis use and sleep quality in daily life: An electronic daily diary study of adults starting cannabis for health concerns.
Tervo-Clemmens B, Schmitt W, Wheeler G, Cooke ME, Schuster RM, Hickey S, Pachas GN, Evins AE, Gilman JM. Drug Alcohol Depend. 2023 Feb 1;243:109760.
Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States.
Rakutt MJ, Mace RA, Conley CEW, Stone AV, Duncan ST, Greenberg J, Landy DC, Vranceanu AM, Jacobs CA. J Aging Health. 2023 Oct;35(9):643-650.
JACLP Guide for Manuscript Peer Review: How to Perform a Peer Review and How to Be Responsive to Reviewer Comments.
Oldham MA, Kontos N, Baller E, Cerimele JM. J Acad Consult Liaison Psychiatry. 2023 Sep-Oct;64(5):468-472. doi: 10.1016/j.jaclp.2023.01.011.
Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology.
Rogers JP, Oldham MA, Fricchione G, Northoff G, Ellen Wilson J, Mann SC, Francis A, Wieck A, Elizabeth Wachtel L, Lewis G, Grover S, Hirjak D, Ahuja N, Zandi MS, Young AH, Fone K, Andrews S, Kessler D, Saifee T, Gee S, Baldwin DS, David AS. J Psychopharmacol. 2023 Apr;37(4):327-369. doi: 10.1177/02698811231158232.
Approaching differential diagnosis and decisional capacity assessment in the context of COVID-19 conspiracy beliefs: A narrative review and clinical discussion.
Serdenes R, Arana F, Karasin J, Kontos N, Musselman M. Gen Hosp Psychiatry. 2023 Jul-Aug;83:75-80.
Children with Rolandic epilepsy have micro- and macrostructural abnormalities in white matter constituting networks necessary for language function.
Ostrowski LM, Chinappen DM, Stoyell SM, Song DY, Ross EE, Kramer MA, Emerton BC, Chu CJ. Epilepsy Behav. 2023 Jul;144:109254. doi: 10.1016/j.yebeh.2023.109254. Epub 2023 May 18.
A Bipolar Learning Health Network: An innovation whose time has come.
Nierenberg AA, Margolis P, Strakowski S, Trivedi M, Yatham LN; Bipolar Disorder Learning Health Network.. Bipolar Disord. 2023 May;25(3):177-180. doi: 10.1111/bdi.13339.
Striatal dopamine in anhedonia: A simultaneous [(11)C]raclopride positron emission tomography and functional magnetic resonance imaging investigation.
Phillips RD, Walsh EC, Zürcher NR, Lalush DS, Kinard JL, Tseng CE, Cernasov PM, Kan D, Cummings K, Kelley L, Campbell D, Dillon DG, Pizzagalli DA, Izquierdo-Garcia D, Hooker JM, Smoski MJ, Dichter GS. Psychiatry Res Neuroimaging. 2023 Aug;333:111660. doi: 10.1016/j.pscychresns.2023.111660. Epub 2023 Jun 1.
Tailoring Psychiatric Neuroimaging to Translational Goals.
Tervo-Clemmens B, Marek S, Barch DM. JAMA Psychiatry. 2023 Aug 1;80(8):765-766. doi: 10.1001/jamapsychiatry.2023.1416.
Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients.
Wu SK, Chen WJ, Chang JP, Guu TW, Hsin MC, Huang CK, Mischoulon D, Capuron L, Su KP. J Pers Med. 2023 Jun 15;13(6). pii: 1003. doi: 10.3390/jpm13061003.
Gender identity and expression in relation to depression and anxiety in racial and ethnic minority youth: Evaluations of intersectionality in a population-based study.
Turnamian MR, Liu RT. J Affect Disord. 2023 Oct 15;339:219-226. doi: 10.1016/j.jad.2023.07.023. Epub 2023 Jul 10.
Metabolomics and Self-Reported Depression, Anxiety, and Phobic Symptoms in the VA Normative Aging Study.
Prince N, Stav M, Cote M, Chu SH, Vyas CM, Okereke OI, Palacios N, Litonjua AA, Vokonas P, Sparrow D, Spiro A III, Lasky-Su JA, Kelly RS. Metabolites. 2023 Jul 15; 13(7): 851.
Frequency-dependent tuning of the human vestibular “sixth sense” by transcranial oscillatory currents.
Rossi S, Cinti A, Viberti F, Benelli A, Neri F, De Monte D, Giannotta A, Romanella S, Smeralda C, Donniacuo A, Prattichizzo D, Pasqualetti P, Santarnecchi E, Mandalà M. Clin Neurophysiol. 2023 Sep;153:123-132. doi: 10.1016/j.clinph.2023.06.013. Epub 2023 Jul 5.
Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.
Sheridan SD, Horng JE, Yeh H, McCrea L, Wang J, Fu T, Perlis RH. Biol Psychiatry. 2023 Aug 11. pii: S0006-3223(23)01489-0. doi: 10.1016/j.biopsych.2023.07.022. [Epub ahead of print]
Neuroimaging research in Williams syndrome: Beginning to bridge the gap with clinical care.
Thom RP, Canales C, Tresvalles M, McDougle CJ, Hooker JM, Chen Y, Zürcher NR. Neurosci Biobehav Rev. 2023 Oct;153:105364. doi: 10.1016/j.neubiorev.2023.105364. Epub 2023 Aug 19. Review.
Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations.
Quade L, Králík M, Bencúrová P, Dunn EC. Int J Paleopathol. 2023 Dec;43:1-6. doi: 10.1016/j.ijpp.2023.08.001. Epub 2023 Aug 26.
Addressing chronic pain disparities between Black and White people: a narrative review of socio-ecological determinants.
Pham TV, Doorley J, Kenney M, Joo JH, Shallcross AJ, Kincade M, Jackson J, Vranceanu AM. Pain Manag. 2023 Aug;13(8):473-496. doi: 10.2217/pmt-2023-0032. Epub 2023 Aug 31. Review.
Mindfulness training and exercise differentially impact fear extinction neurocircuitry.
Leibovitz SE, Sevinc G, Greenberg J, Hölzel B, Gard T, Calahan T, Vangel M, Orr SP, Milad MR, Lazar SW. Psychol Med. 2023 Sep 1:1-12. doi: 10.1017/S0033291723002593. [Epub ahead of print]
The house is a machine for everything: the role of the built environment in group homes during the COVID-19 pandemic.
Oreskovic NM, Donelan K, Bartels SJ, Chau C, Irwin KE, Krane D, Levison JH, Michael C, Trieu H, Skotko BG. Public Health. 2023 Sep 9;224:20-25. doi: 10.1016/j.puhe.2023.08.012. [Epub ahead of print]
Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy.
Winter SF, Vaios EJ, Shih HA, Grassberger C, Parsons MW, Gardner MM, Ehret F, Kaul D, Boehmerle W, Endres M, Dietrich J. Curr Treat Options Oncol. 2023 Nov;24(11):1524-1549. doi: 10.1007/s11864-023-01131-x. Epub 2023 Sep 20. Review.
Consumption of Ultraprocessed Food and Risk of Depression.
Samuthpongtorn C, Nguyen LH, Okereke OI, Wang DD, Song M, Chan AT, Mehta RS. JAMA Network Open. 2023 Sep 20; 6(9): e2334770
Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults: Protocol for the Active Brains Remote Efficacy Trial.
Vranceanu AM, Choukas NR, Rochon EA, Duarte B, Pietrzykowski MO, McDermott K, Hooker JE, Kulich R, Quiroz YT, Parker RA, Macklin EA, Ritchie C; Active Brains Project., Mace RA. JMIR Res Protoc. 2023 Sep 28;12:e47319. doi: 10.2196/47319.
Misinformation, Trust, and Use of Ivermectin and Hydroxychloroquine for COVID-19.
Perlis RH, Lunz Trujillo K, Green J, Safarpour A, Druckman JN, Santillana M, Ognyanova K, Lazer D. JAMA Health Forum. 2023 Sep 1;4(9):e233257. doi: 10.1001/jamahealthforum.2023.3257. Erratum in: JAMA Health Forum. 2023 Oct 6;4(10):e234083.
Evaluating the Application of Large Language Models in Clinical Research Contexts.
Perlis RH, Fihn SD. JAMA Netw Open. 2023 Oct 2;6(10):e2335924. doi: 10.1001/jamanetworkopen.2023.35924.
The effect of neighborhood socioeconomic disadvantage on smoking status, quit attempts, and receipt of cessation support among adults with cancer: Results from nine ECOG-ACRIN Cancer Research Group (EA) trials.
Walter AW, Lee JW, Streck JM, Gareen IF, Herman BA, Kircher SM, Carlos RC, Kumar SK, Mayer IA, Saba NF, Fenske TS, Neal JW, Atkins MB, Hodi FS, Kyriakopoulos CE, Tempany-Afdhal CM, Shanafelt TD, Wagner LI, Land SR, Ostroff JS, Park ER. Cancer. 2023 Oct 5. doi: 10.1002/cncr.35039. [Epub ahead of print]
An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Shih YT, Alipio JB, Sahay A. Neuron. 2023 Oct 4;111(19):3084-3101.e5. doi: 10.1016/j.neuron.2023.09.009.
Diagnosis and Treatment of Bipolar Disorder: A Review.
Nierenberg AA, Agustini B, Köhler-Forsberg O, Cusin C, Katz D, Sylvia LG, Peters A, Berk M. JAMA. 2023 Oct 10;330(14):1370-1380. doi: 10.1001/jama.2023.18588. Review.
Integrating Lifestyle Factor Science into Neuropsychological Practice: A National Academy of Neuropsychology Education Paper.
Randolph JJ, Lacritz LH, Colvin MK, Espe-Pfeifer P, Carter KR, Arnett PA, Fox-Fuller J, Aduen PA, Cullum CM, Sperling SA. Arch Clin Neuropsychol. 2023 Oct 23. pii: acad078. doi: 10.1093/arclin/acad078. [Epub ahead of print]
A Mindfulness-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injury Transitioning Out of Critical Care: Protocol for an Open Pilot Trial.
Presciutti AM, Woodworth E, Rochon E, Neale M, Motta M, Piazza J, Vranceanu AM, Hwang DY. JMIR Res Protoc. 2023 Oct 25;12:e50860. doi: 10.2196/50860.
Within-Person Modulation of Neural Networks following Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (MABT): A Pilot Study.
Price CJ, Sevinc G, Farb NAS. Brain Sci. 2023 Sep 30;13(10). pii: 1396. doi: 10.3390/brainsci13101396.
Firearm Injuries In Children And Adolescents: Health And Economic Consequences Among Survivors And Family Members.
Song Z, Zubizarreta JR, Giuriato M, Koh KA, Sacks CA. Health Aff (Millwood). 2023 Nov;42(11):1541-1550. doi: 10.1377/hlthaff.2023.00587.
Apolipoprotein E and its association with cognitive change and modification of treatment effects of vitamin D3 and omega-3s on cognitive change: results from the in-clinic subset of a randomized clinical trial.
Vyas CM, Kang JH, Mischoulon D, Cook NR, Reynolds CF 3rd, Chang G, Mora S, De Vivo I, Manson JAE, Okereke OI. J Gerontol A Biol Sci Med Sci. 2023 Nov 11. pii: glad260. doi: 10.1093/gerona/glad260. [Epub ahead of print]
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, Reiman EM, Mahley RW, Huang Y. Nat Neurosci. 2023 Dec;26(12):2104-2121. doi: 10.1038/s41593-023-01480-8. Epub 2023 Nov 13.
Clinician Perceptions of Barriers and Facilitators for Delivering Early Integrated Palliative Care via Telehealth.
Sadang KG, Centracchio JA, Turk Y, Park E, Feliciano JL, Chua IS, Blackhall L, Silveira MJ, Fischer SM, Rabow M, Zachariah F, Grey C, Campbell TC, Strand J, Temel JS, Greer JA. Cancers (Basel). 2023 Nov 9;15(22). pii: 5340. doi: 10.3390/cancers15225340.
Integrating Psychosocial Care into Orthopedic Settings: A Qualitative Study of Provider Perspectives.
Reichman M, Briskin EA, Duarte BA, Vranceanu AM, Grunberg VA. Int J Integr Care. 2023 Dec 6;23(4):15. doi: 10.5334/ijic.7579. eCollection 2023 Oct-Dec.
The Developmental Timing but Not Magnitude of Adolescent Risk-Taking Propensity Is Consistent Across Social, Environmental, and Psychological Factors.
Tervo-Clemmens B, Karim ZA, Khan SZ, Ravindranath O, Somerville LH, Schuster RM, Gilman JM, Evins AE. J Adolesc Health. 2023 Dec 11. pii: S1054-139X(23)00572-4. doi: 10.1016/j.jadohealth.2023.11.001. [Epub ahead of print]
Telemedicine-Based Cognitive Examinations During COVID-19 and Beyond: Perspective of the Massachusetts General Hospital Behavioral Neurology & Neuropsychiatry Group.
Tanev KS, Camprodon JA, Caplan DN, Dickerson BC, Chemali Z, Eldaief MC, Kim DD, Josephy-Hernandez SE, Kritzer MD, Moo LR, Newhouse A, Perez DL, Ramirez Gomez LA, Razafsha M, Rivas-Grajales AM, Scharf JM, Schmahmann JD, Sherman JC. J Neuropsychiatry Clin Neurosci. 2023 Dec 19:appineuropsych20220154. doi: 10.1176/appi.neuropsych.20220154. [Epub ahead of print]
Wearable Technology in Clinical Practice for Depressive Disorder.
Fedor S, Lewis R, Pedrelli P, Mischoulon D, Curtiss J, Picard RW. N Engl J Med. 2023 Dec 28;389(26):2457-2466. doi: 10.1056/NEJMra2215898. Review. No abstract available.
