The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
Mindfulness, coping, and optimism as mechanisms of change in the 3RP-NF intervention.
Grunberg VA, Bakhshaie J, Manglani H, Hooker J, Rochon EA, Vranceanu AM.
J Clin Psychol. 2024 Feb;80(2):456-470.
Dermatology’s role in the fight against human trafficking: A report from the AAD Ad Hoc Task Force and call to action.
Pollock S, Ferree S, Cronin M, Judge AM, Berson DS, Friedman PM, Grimes PE, Murase JE, Freeman EE, Rao M, Malik S, Balk R, Miller J, Cronin TA Jr, Kourosh AS. J Am Acad Dermatol. 2024 Feb;90(2):339-341.
Substance Use, Suicidal Thoughts, and Psychiatric Comorbidities Among High School Students.
Tervo-Clemmens B, Gilman JM, Evins AE, Bentley KH, Nock MK, Smoller JW, Schuster RM. JAMA Pediatr. 2024 Jan 29.
Bio-Experiential Technology to Support Persons With Dementia and Care Partners at Home (TEND): Protocol for an Intervention Development Study.
Rochon EA, Sy M, Phillips M, Anderson E, Plys E, Ritchie C, Vranceanu AM. JMIR Res Protoc. 2023 Dec 29;12:e52799.
Stimulant Treatment and Potential Adverse Outcomes in Pediatric Populations With Bipolar Disorder: A Systematic Review of the Literature.
O’Connor H, Hutt Vater C, DiSalvo M, Faraone SV, Wozniak J. J Atten Disord. 2023 Dec 29:10870547231218045.
Interpreting clinical trial outcomes complicated by placebo response with an assessment of false-negative and true-negative clinical trials in depression using propensity-weighting.
Gomeni R, Hopkins S, Bressolle-Gomeni F, Fava M. Transl Psychiatry. 2023 Dec 14;13(1):388.
“When Will All of This End?”: A 65-Year-Old Man With Amyotrophic Lateral Sclerosis and Psychiatric Distress.
Lester EG, Vitolo OV, Flaherty A, Beaussant Y, Cramer M, Harley R, Cohen JN. J Clin Psychiatry. 2023 Dec 13;85(1):23ct15038.
Palliative Care Clinical Trials in Underrepresented Ethnic and Racial Minorities: A Narrative Review.
Sy M, Ritchie CS, Vranceanu AM, Bakhshaie J. J Palliat Med. 2023 Dec 8.
Prenatal Polysubstance Use and Attention-Deficit/Hyperactivity Disorder (ADHD).
Ryan JE, McCabe SE, Wilens TE, Weigard A, Worster B, Veliz P. Am J Prev Med. 2023 Dec 7:S0749-3797(23)00483-X.
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Nat Med. 2023 Dec;29(12):3184-3192.
Incidence of opioid misuse by cigarette smoking status in the United States.
Parker MA, Cruz-Cano R, Streck JM, Ballis E, Weinberger AH. Addict Behav. 2023 Dec;147:107837.
Editorial: Height and Stimulant Treatment in Attention-Deficit/Hyperactivity Disorder Youth: Mind the Gap.
Wilens T, Stone M, Spencer TJ. J Am Acad Child Adolesc Psychiatry. 2023 Dec;62(12):1305-1307.
Prescribed and Penalized: The Detrimental Impact of Mandated Reporting for Prenatal Utilization of Medication for Opioid Use Disorder.
Work EC, Muftu S, MacMillan KDL, Gray JR, Bell N, Terplan M, Jones HE, Reddy J, Wilens TE, Greenfield SF, Bernstein J, Schiff DM. Matern Child Health J. 2023 Dec;27(Suppl 1):104-112.
Distinguishing and treating demoralization syndrome in cancer: A review.
Fava M, Sorg E, Jacobs JM, Leadbetter R, Guidi J. Gen Hosp Psychiatry. 2023 Nov-Dec;85:185-190.
Cariprazine for the Adjunctive Treatment of Major Depressive Disorder in Patients With Inadequate Response to Antidepressant Therapy: Results of a Randomized, Double-Blind, Placebo-Controlled Study.
Riesenberg R, Yeung PP, Rekeda L, Sachs GS, Kerolous M, Fava M. J Clin Psychiatry. 2023 Aug 16;84(5):22m14643.
Cocaine or Methamphetamine Use During Young Adulthood Following Stimulant Use for Attention-Deficit/Hyperactivity Disorder During Adolescence.
McCabe SE, Schulenberg JE, Wilens TE, Schepis TS, McCabe VV, Veliz PT. JAMA Netw Open. 2023 Jul 3;6(7):e2322650.
Assessing the clinical utility of toxicology testing in the peripartum period.
Siegel MR, Cohen SJ, Koenigs K, Woods GT, Schwartz LN, Sarathy L, Chou JH, Terplan M, Wilens T, Ecker JL, Bernstein SN, Schiff DM. Am J Obstet Gynecol MFM. 2023 Jul;5(7):100963.
The Heritability of ADHD in Children of ADHD Parents: A Post-hoc Analysis of Longitudinal Data.
Uchida M, DiSalvo M, Walsh D, Biederman J. J Atten Disord. 2023 Feb;27(3):250-257.
Reducing Health Care’s Climate Impact – Mission Critical or Extra Credit?
Rabin AS, Pinsky EG. N Engl J Med. 2023 Aug 17;389(7):583-585.
Gender identity and expression in relation to depression and anxiety in racial and ethnic minority youth: Evaluations of intersectionality in a population-based study.
Turnamian MR, Liu RT. J Affect Disord. 2023 Oct 15;339:219-226. doi: 10.1016/j.jad.2023.07.023. Epub 2023 Jul 10.
Metabolomics and Self-Reported Depression, Anxiety, and Phobic Symptoms in the VA Normative Aging Study.
Prince N, Stav M, Cote M, Chu SH, Vyas CM, Okereke OI, Palacios N, Litonjua AA, Vokonas P, Sparrow D, Spiro A III, Lasky-Su JA, Kelly RS. Metabolites. 2023 Jul 15; 13(7): 851.
Frequency-dependent tuning of the human vestibular “sixth sense” by transcranial oscillatory currents.
Rossi S, Cinti A, Viberti F, Benelli A, Neri F, De Monte D, Giannotta A, Romanella S, Smeralda C, Donniacuo A, Prattichizzo D, Pasqualetti P, Santarnecchi E, Mandalà M. Clin Neurophysiol. 2023 Sep;153:123-132. doi: 10.1016/j.clinph.2023.06.013. Epub 2023 Jul 5.
Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.
Sheridan SD, Horng JE, Yeh H, McCrea L, Wang J, Fu T, Perlis RH. Biol Psychiatry. 2023 Aug 11. pii: S0006-3223(23)01489-0. doi: 10.1016/j.biopsych.2023.07.022. [Epub ahead of print]
Neuroimaging research in Williams syndrome: Beginning to bridge the gap with clinical care.
Thom RP, Canales C, Tresvalles M, McDougle CJ, Hooker JM, Chen Y, Zürcher NR. Neurosci Biobehav Rev. 2023 Oct;153:105364. doi: 10.1016/j.neubiorev.2023.105364. Epub 2023 Aug 19. Review.
Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations.
Quade L, Králík M, Bencúrová P, Dunn EC. Int J Paleopathol. 2023 Dec;43:1-6. doi: 10.1016/j.ijpp.2023.08.001. Epub 2023 Aug 26.
Addressing chronic pain disparities between Black and White people: a narrative review of socio-ecological determinants.
Pham TV, Doorley J, Kenney M, Joo JH, Shallcross AJ, Kincade M, Jackson J, Vranceanu AM. Pain Manag. 2023 Aug;13(8):473-496. doi: 10.2217/pmt-2023-0032. Epub 2023 Aug 31. Review.
Mindfulness training and exercise differentially impact fear extinction neurocircuitry.
Leibovitz SE, Sevinc G, Greenberg J, Hölzel B, Gard T, Calahan T, Vangel M, Orr SP, Milad MR, Lazar SW. Psychol Med. 2023 Sep 1:1-12. doi: 10.1017/S0033291723002593. [Epub ahead of print]
The house is a machine for everything: the role of the built environment in group homes during the COVID-19 pandemic.
Oreskovic NM, Donelan K, Bartels SJ, Chau C, Irwin KE, Krane D, Levison JH, Michael C, Trieu H, Skotko BG. Public Health. 2023 Sep 9;224:20-25. doi: 10.1016/j.puhe.2023.08.012. [Epub ahead of print]
Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy.
Winter SF, Vaios EJ, Shih HA, Grassberger C, Parsons MW, Gardner MM, Ehret F, Kaul D, Boehmerle W, Endres M, Dietrich J. Curr Treat Options Oncol. 2023 Nov;24(11):1524-1549. doi: 10.1007/s11864-023-01131-x. Epub 2023 Sep 20. Review.
Consumption of Ultraprocessed Food and Risk of Depression.
Samuthpongtorn C, Nguyen LH, Okereke OI, Wang DD, Song M, Chan AT, Mehta RS. JAMA Network Open. 2023 Sep 20; 6(9): e2334770
Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults: Protocol for the Active Brains Remote Efficacy Trial.
Vranceanu AM, Choukas NR, Rochon EA, Duarte B, Pietrzykowski MO, McDermott K, Hooker JE, Kulich R, Quiroz YT, Parker RA, Macklin EA, Ritchie C; Active Brains Project., Mace RA. JMIR Res Protoc. 2023 Sep 28;12:e47319. doi: 10.2196/47319.
Misinformation, Trust, and Use of Ivermectin and Hydroxychloroquine for COVID-19.
Perlis RH, Lunz Trujillo K, Green J, Safarpour A, Druckman JN, Santillana M, Ognyanova K, Lazer D. JAMA Health Forum. 2023 Sep 1;4(9):e233257. doi: 10.1001/jamahealthforum.2023.3257. Erratum in: JAMA Health Forum. 2023 Oct 6;4(10):e234083.
Evaluating the Application of Large Language Models in Clinical Research Contexts.
Perlis RH, Fihn SD. JAMA Netw Open. 2023 Oct 2;6(10):e2335924. doi: 10.1001/jamanetworkopen.2023.35924.
The effect of neighborhood socioeconomic disadvantage on smoking status, quit attempts, and receipt of cessation support among adults with cancer: Results from nine ECOG-ACRIN Cancer Research Group (EA) trials.
Walter AW, Lee JW, Streck JM, Gareen IF, Herman BA, Kircher SM, Carlos RC, Kumar SK, Mayer IA, Saba NF, Fenske TS, Neal JW, Atkins MB, Hodi FS, Kyriakopoulos CE, Tempany-Afdhal CM, Shanafelt TD, Wagner LI, Land SR, Ostroff JS, Park ER. Cancer. 2023 Oct 5. doi: 10.1002/cncr.35039. [Epub ahead of print]
An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Shih YT, Alipio JB, Sahay A. Neuron. 2023 Oct 4;111(19):3084-3101.e5. doi: 10.1016/j.neuron.2023.09.009.
Diagnosis and Treatment of Bipolar Disorder: A Review.
Nierenberg AA, Agustini B, Köhler-Forsberg O, Cusin C, Katz D, Sylvia LG, Peters A, Berk M. JAMA. 2023 Oct 10;330(14):1370-1380. doi: 10.1001/jama.2023.18588. Review.
Integrating Lifestyle Factor Science into Neuropsychological Practice: A National Academy of Neuropsychology Education Paper.
Randolph JJ, Lacritz LH, Colvin MK, Espe-Pfeifer P, Carter KR, Arnett PA, Fox-Fuller J, Aduen PA, Cullum CM, Sperling SA. Arch Clin Neuropsychol. 2023 Oct 23. pii: acad078. doi: 10.1093/arclin/acad078. [Epub ahead of print]
A Mindfulness-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injury Transitioning Out of Critical Care: Protocol for an Open Pilot Trial.
Presciutti AM, Woodworth E, Rochon E, Neale M, Motta M, Piazza J, Vranceanu AM, Hwang DY. JMIR Res Protoc. 2023 Oct 25;12:e50860. doi: 10.2196/50860.
Within-Person Modulation of Neural Networks following Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (MABT): A Pilot Study.
Price CJ, Sevinc G, Farb NAS. Brain Sci. 2023 Sep 30;13(10). pii: 1396. doi: 10.3390/brainsci13101396.
Firearm Injuries In Children And Adolescents: Health And Economic Consequences Among Survivors And Family Members.
Song Z, Zubizarreta JR, Giuriato M, Koh KA, Sacks CA. Health Aff (Millwood). 2023 Nov;42(11):1541-1550. doi: 10.1377/hlthaff.2023.00587.
Apolipoprotein E and its association with cognitive change and modification of treatment effects of vitamin D3 and omega-3s on cognitive change: results from the in-clinic subset of a randomized clinical trial.
Vyas CM, Kang JH, Mischoulon D, Cook NR, Reynolds CF 3rd, Chang G, Mora S, De Vivo I, Manson JAE, Okereke OI. J Gerontol A Biol Sci Med Sci. 2023 Nov 11. pii: glad260. doi: 10.1093/gerona/glad260. [Epub ahead of print]
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, Reiman EM, Mahley RW, Huang Y. Nat Neurosci. 2023 Dec;26(12):2104-2121. doi: 10.1038/s41593-023-01480-8. Epub 2023 Nov 13.
Clinician Perceptions of Barriers and Facilitators for Delivering Early Integrated Palliative Care via Telehealth.
Sadang KG, Centracchio JA, Turk Y, Park E, Feliciano JL, Chua IS, Blackhall L, Silveira MJ, Fischer SM, Rabow M, Zachariah F, Grey C, Campbell TC, Strand J, Temel JS, Greer JA. Cancers (Basel). 2023 Nov 9;15(22). pii: 5340. doi: 10.3390/cancers15225340.
Integrating Psychosocial Care into Orthopedic Settings: A Qualitative Study of Provider Perspectives.
Reichman M, Briskin EA, Duarte BA, Vranceanu AM, Grunberg VA. Int J Integr Care. 2023 Dec 6;23(4):15. doi: 10.5334/ijic.7579. eCollection 2023 Oct-Dec.
The Developmental Timing but Not Magnitude of Adolescent Risk-Taking Propensity Is Consistent Across Social, Environmental, and Psychological Factors.
Tervo-Clemmens B, Karim ZA, Khan SZ, Ravindranath O, Somerville LH, Schuster RM, Gilman JM, Evins AE. J Adolesc Health. 2023 Dec 11. pii: S1054-139X(23)00572-4. doi: 10.1016/j.jadohealth.2023.11.001. [Epub ahead of print]
Telemedicine-Based Cognitive Examinations During COVID-19 and Beyond: Perspective of the Massachusetts General Hospital Behavioral Neurology & Neuropsychiatry Group.
Tanev KS, Camprodon JA, Caplan DN, Dickerson BC, Chemali Z, Eldaief MC, Kim DD, Josephy-Hernandez SE, Kritzer MD, Moo LR, Newhouse A, Perez DL, Ramirez Gomez LA, Razafsha M, Rivas-Grajales AM, Scharf JM, Schmahmann JD, Sherman JC. J Neuropsychiatry Clin Neurosci. 2023 Dec 19:appineuropsych20220154. doi: 10.1176/appi.neuropsych.20220154. [Epub ahead of print]
Wearable Technology in Clinical Practice for Depressive Disorder.
Fedor S, Lewis R, Pedrelli P, Mischoulon D, Curtiss J, Picard RW. N Engl J Med. 2023 Dec 28;389(26):2457-2466. doi: 10.1056/NEJMra2215898. Review. No abstract available.
