The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
Apolipoprotein E and its association with cognitive change and modification of treatment effects of vitamin D3 and omega-3s on cognitive change: results from the in-clinic subset of a randomized clinical trial.
Vyas CM, Kang JH, Mischoulon D, Cook NR, Reynolds CF 3rd, Chang G, Mora S, De Vivo I, Manson JAE, Okereke OI. J Gerontol A Biol Sci Med Sci. 2023 Nov 11:glad260.
Neuropsychiatric adverse effects from CFTR modulators deserve a serious research effort.
VanElzakker MB, Tillman EM, Yonker LM, Ratai EM, Georgiopoulos AM. Curr Opin Pulm Med. 2023 Nov 1;29(6):603-609.
Mindfulness-Based App to Reduce Stress in Caregivers of Persons With Alzheimer Disease and Related Dementias: Protocol for a Single-Blind Feasibility Proof-of-Concept Randomized Controlled Trial.
Woodworth EC, Briskin EA, Plys E, Macklin E, Tatar RG, Huberty J, Vranceanu AM. JMIR Res Protoc. 2023 Oct 13;12:e50108.
Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults: Protocol for the Active Brains Remote Efficacy Trial.
Vranceanu AM, Choukas NR, Rochon EA, Duarte B, Pietrzykowski MO, McDermott K, Hooker JE, Kulich R, Quiroz YT, Parker RA, Macklin EA, Ritchie C; Active Brains Project; Mace RA. JMIR Res Protoc. 2023 Sep 28;12:e47319.
Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies.
Sbarra DA, Ramadan FA, Choi KW, Treur JL, Levey DF, Wootton RE, Stein MB, Gelernter J, Klimentidis YC. Mol Psychiatry. 2023 Sep 21.
Bone Density, Geometry, Structure and Strength Estimates in Adolescent and Young Adult Women with Atypical Anorexia Nervosa versus Typical Anorexia Nervosa and Normal-Weight Healthy Controls.
Tuli S, Singhal V, Slattery M, Gupta N, Brigham KS, Rosenblum J, Ebrahimi S, Eddy KT, Miller KK, Misra M. Nutrients. 2023 Sep 12;15(18):3946.
The impact of COVID-19 on older minority adults in the United States: challenges and potential solutions.
Touma Sawaya R, Touma M, Gutierrez-Martinez L, Josephy-Hernandez S, Chemali Z. Psychogeriatrics. 2023 Sep;23(5):891-893.
The Intersection of Disorders of Gut-Brain Interaction With Avoidant/Restrictive Food Intake Disorder.
Weeks I, Abber SR, Thomas JJ, Calabrese S, Kuo B, Staller K, Murray HB. J Clin Gastroenterol. 2023 Aug 1;57(7):651-662.
Cognitive behavioral therapy (CBT) plus attention bias modification (ABM) reduces anxiety sensitivity and depressive symptoms in panic disorder: A pilot randomized trial.
Zainal NH, Hellberg SN, Kabel KE, Hotchkin CM, Baker AW. Scand J Psychol. 2023 Aug;64(4):390-400.
Patterns of pharmacotherapy for bipolar disorder: A GBC survey.
Singh B, Yocum AK, Strawbridge R, Burdick KE, Millett CE, Peters AT, Sperry SH, Fico G, Vieta E, Verdolini N, Godin O, Leboyer M, Etain B, Tso IF, Coombes BJ, McInnis MG, Nierenberg AA, Young AH, Ashton MM, Berk M, Williams LJ, Keramatian K, Yatham LN, Overs BJ, Fullerton JM, Roberts G, Mitchell PB, Andreassen OA, Andreazza AC, Zandi PP, Pham D, Biernacka JM, Frye MA; FACE-BD Collaborators, The Global Bipolar Cohort Collaborative. Bipolar Disord. 2023 Jul 18.
Low bone mineral density is found in low weight female youth with avoidant/restrictive food intake disorder and associated with higher PYY levels.
Sella AC, Becker KR, Slattery M, Hauser K, Asanza E, Stern C, Kuhnle M, Micali N, Eddy KT, Misra M, Thomas JJ, Lawson EA. J Eat Disord. 2023 Jul 1;11(1):106.
The effect of HD-tDCS on brain oscillations and frontal synchronicity during resting-state EEG in violent offenders with a substance dependence.
Sergiou CS, Tatti E, Romanella SM, Santarnecchi E, Weidema AD, Rassin EGC, Franken IHA, van Dongen JDM. Int J Clin Health Psychol. 2023 Jul-Sep;23(3):100374.
“I Know Myself Again, Which Makes Me Motivated for Life”: Feasibility and Acceptability of Using Experience Sampling Methods With Trauma-Exposed Sexual Minority Women.
Scheer JR, Cascalheira CJ, Helminen EC, Shaw TJ, Schwarz AA, Jaipuriar V, Brisbin CD, Batchelder AW, Sullivan TP, Jackson SD. J Interpers Violence. 2023 Jul;38(13-14):8692-8720.
Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients.
Wu SK, Chen WJ, Chang JP, Guu TW, Hsin MC, Huang CK, Mischoulon D, Capuron L, Su KP. J Pers Med. 2023 Jun 15;13(6):1003.
Emulating a Target Trial of Dynamic Treatment Strategies for Major Depressive Disorder Using Data From the STAR∗D Randomized Trial.
Szmulewicz AG, Wanis KN, Perlis RH, Hernández-Díaz S, Öngür D, Hernán MA. Biol Psychiatry. 2023 Jun 15;93(12):1127-1136.
Effect of Mind-Body Skills Training on Quality of Life for Geographically Diverse Adults With Neurofibromatosis: A Fully Remote Randomized Clinical Trial.
Vranceanu AM, Manglani HR, Choukas NR, Kanaya MR, Lester E, Zale EL, Plotkin SR, Jordan J, Macklin E, Bakhshaie J. JAMA Netw Open. 2023 Jun 1;6(6):e2320599.
Injection of Methamphetamine Has Increased in Boston, Massachusetts: 5 Waves of Centers for Disease Control and Prevention State Surveillance Data.
Streck JM, Klevens RM, O’Cleirigh C, Batchelder AW. J Addict Med. 2023 May-Jun 01;17(3):349-352.
A New Treatment Program: Focused Integrated Team-based Treatment Program for Bipolar Disorder (FITT-BD).
Sylvia LG, Tovey RE, Katz D, Boccagno C, Stromberg AR, Peters AT, Temes CM, Gold AK, Mow J, Puvanich N, Albury EA, Stephan NJ, Faria CM, Nierenberg AA, Kamali MP. J Psychiatr Pract. 2023 May 1;29(3):176-188.
An efficient landmark model for prediction of suicide attempts in multiple clinical settings.
Sheu YH, Sun J, Lee H, Castro VM, Barak-Corren Y, Song E, Madsen EM, Gordon WJ, Kohane IS, Churchill SE, Reis BY, Cai T, Smoller JW. Psychiatry Res. 2023 May;323:115175.
Characterizing observed and effective behavioral engagement with smartphone cognitive behavioral therapy for body dysmorphic disorder: A methods roadmap and use case.
Weingarden H, Garriga Calleja R, Greenberg JL, Snorrason I, Matic A, Quist R, Harrison O, Hoeppner SS, Wilhelm S. Internet Interv. 2023 Mar 16;32:100615.
Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.
Siecinski SK, Giamberardino SN, Spanos M, Hauser AC, Gibson JR, Chandrasekhar T, Trelles MDP, Rockhill CM, Palumbo ML, Cundiff AW, Montgomery A, Siper P, Minjarez M, Nowinski LA, Marler S, Kwee LC, Shuffrey LC, Alderman C, Weissman J, Zappone B, Mullett JE, Crosson H, Hong N, Luo S, She L, Bhapkar M, Dean R, Scheer A, Johnson JL, King BH, McDougle CJ, Sanders KB, Kim SJ, Kolevzon A, Veenstra-VanderWeele J, Hauser ER, Sikich L, Gregory SG. Autism Res. 2023 Mar;16(3):502-523.
Hypertension differentially impacts cognition in men and women in early midlife.
Shields HL, Konishi K, Aroner S, Aizley H, Remington A, Lee H, Buka S, Goldstein JM. J Neuropsychol. 2023 Mar;17(1):146-160.
Patients With Serious Mental Illness Can Engage in Tobacco Treatment Trials and Tobacco Cessation Interventions During Cancer Treatment.
Steffens EB, Park ER, Muzikansky A, Streck JM, Ostroff JS, Rasmussen AW, Ponzani C, Perez GK, Regan S, Rigotti NA, Irwin KE. JCO Oncol Pract. 2023 Feb;19(2):e238-e247.
Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.
Stein MB, Jain S, Parodi L, Choi KW, Maihofer AX, Nelson LD, Mukherjee P, Sun X, He F, Okonkwo DO, Giacino JT, Korley FK, Vassar MJ, Robertson CS, McCrea MA, Temkin N, Markowitz AJ, Diaz-Arrastia R, Rosand J, Manley GT; TRACK-TBI Investigators. Transl Psychiatry. 2023 Jan 25;13(1):24.
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens.
Wang Y, Fan JL, Melms JC, Amin AD, Georgis Y, Barrera I, Ho P, Tagore S, Abril-Rodríguez G, He S, Jin Y, Biermann J, Hofree M, Caprio L, Berhe S, Khan SA, Henick BS, Ribas A, Macosko EZ, Chen F, Taylor AM, Schwartz GK, Carvajal RD, Azizi E, Izar B. Nat Genet. 2023 Jan;55(1):19-25.
Healthy hearts healthy minds: A randomized trial of online interventions to improve physical activity.
Sylvia LG, Gold AK, Rakhilin M, Amado S, Modrow MF, Albury EA, George N, Peters AT, Selvaggi CA, Horick N, Rabideau DJ, Dohse H, Tovey RE, Turner JA, Schopfer DW, Pletcher MJ, Katz D, Deckersbach T, Nierenberg AA. J Psychosom Res. 2023 Jan;164:111110.
