The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs. Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness.
These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.
A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.
Chen CH, Newman LN, Stark AP, Bond KE, Zhang D, Nardone S, Vanderburg CR, Nadaf NM, Yao Z, Mutume K, Flaquer I, Lowell BB, Macosko EZ, Regehr WG. Nat Neurosci. 2023 Nov;26(11):1929-1941.
Recent contributions to the field of subjective cognitive decline in aging: A literature review.
Munro CE, Boyle R, Chen X, Coughlan G, Gonzalez C, Jutten RJ, Martinez J, Orlovsky I, Robinson T, Weizenbaum E, Pluim CF, Quiroz-Gaviria YT, Gatchel JR, Vannini P, Amariglio R. Alzheimers Dement (Amst). 2023 Oct 18;15(4):e12475.
Trends in Attention-Deficit Hyperactivity Disorder Diagnosis and Pharmacotherapy Among Adults With Opioid Use Disorder.
Park TW, Baul TD, Morgan JR, Wilens TE, Yule AM. Psychiatr Serv. 2023 Oct 4:appips20220400.
Youth Team Sports Participation Associates With Reduced Dimensional Psychopathology Through Interaction With Biological Risk Factors.
Kunitoki K, Hughes D, Elyounssi S, Hopkinson CE, Bazer OM, Eryilmaz H, Dunn EC, Lee PH, Doyle AE, Roffman JL. Biol Psychiatry Glob Open Sci. 2023 Feb 10;3(4):875-883.
Who affiliates with SMART recovery? A comparison of individuals attending SMART recovery, alcoholics anonymous, both, or neither.
Kelly JF, Levy S, Matlack M, Hoeppner BB. Alcohol Clin Exp Res (Hoboken). 2023 Oct;47(10):1926-1942.
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).
Proal AD, VanElzakker MB, Aleman S, Bach K, Boribong BP, Buggert M, Cherry S, Chertow DS, Davies HE, Dupont CL, Deeks SG, Eimer W, Ely EW, Fasano A, Freire M, Geng LN, Griffin DE, Henrich TJ, Iwasaki A, Izquierdo-Garcia D, Locci M, Mehandru S, Painter MM, Peluso MJ, Pretorius E, Price DA, Putrino D, Scheuermann RH, Tan GS, Tanzi RE, VanBrocklin HF, Yonker LM, Wherry EJ. Nat Immunol. 2023 Oct;24(10):1616-1627.
The relationship between mindfulness and enduring somatic threat severity in long-term cardiac arrest survivors.
Presciutti AM, Bannon SM, Yamin JB, Newman MM, Parker RA, Elmer J, Wu O, Donnino MW, Perman SM, Vranceanu AM. J Behav Med. 2023 Oct;46(5):890-896.
Reattribution to Mind-Brain Processes and Recovery From Chronic Back Pain: A Secondary Analysis of a Randomized Clinical Trial.
Ashar YK, Lumley MA, Perlis RH, Liston C, Gunning FM, Wager TD. JAMA Netw Open. 2023 Sep 5;6(9):e2333846.
Responses to bright light exposure in individuals with binge-spectrum eating disorders characterized by high dietary restraint and negative affect.
Kambanis PE, Bottera AR, De Young KP. Int J Eat Disord. 2023 Aug 30.
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions.
Maury EA, Sherman MA, Genovese G, Gilgenast TG, Kamath T, Burris SJ, Rajarajan P, Flaherty E, Akbarian S, Chess A, McCarroll SA, Loh PR, Phillips-Cremins JE, Brennand KJ, Macosko EZ, Walters JTR, O’Donovan M, Sullivan P; Psychiatric Genomic Consortium Schizophrenia and CNV workgroup; Brain Somatic Mosaicism Network; Sebat J, Lee EA, Walsh CA. Cell Genom. 2023 Jul 6;3(8):100356.
Validation of the youth-nine item avoidant/restrictive food intake disorder screen.
Billman Miller MG, Zickgraf HF, Murray HB, Essayli JH, Lane-Loney SE. Eur Eat Disord Rev. 2023 Aug 6.
Senior Resident as Junior Supervisor: Case Report of an Apprenticeship Model for Training Psychotherapy Supervisors.
Belcher R, MacLean RL, Beach SR, Waldinger RJ. Am J Psychother. 2023 Aug 4:0.
Resiliency Intervention for Siblings of Children With Autism Spectrum Disorder: A Randomized Pilot Trial.
Kuhlthau KA, Traeger L, Luberto CM, Perez GK, Goshe BM, Fell L, Iannuzzi D, Park ER. Acad Pediatr. 2023 Aug;23(6):1187-1195.
Pragmatic fidelity measurement in youth service settings.
Wang L, Stoll SJ, Eddy CJ, Hurley S, Sisson J, Thompson N, Raftery-Helmer JN, Ablon JS, Pollastri AR. Implement Res Pract. 2023 Jul 19;4:26334895231185380.
Pre-treatment amygdala activation and habituation predict symptom change in post-traumatic stress disorder.
Hinojosa CA, VanElzakker MB, Kaur N, Felicione JM, Charney ME, Bui E, Marques L, Summergrad P, Rauch SL, Simon NM, Shin LM. Front Behav Neurosci. 2023 Jul 10;17:1198244.
Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis.
Sampath Kumar A, Tian L, Bolondi A, Hernández AA, Stickels R, Kretzmer H, Murray E, Wittler L, Walther M, Barakat G, Haut L, Elkabetz Y, Macosko EZ, Guignard L, Chen F, Meissner A. Nat Genet. 2023 Jul;55(7):1176-1185.
Psychological Resilience to Trauma and Risk of COVID-19 Infection and Somatic Symptoms Across 2 Years.
Nishimi K, Tan J, Scoglio A, Choi KW, Kelley DP, Neylan TC, O’Donovan A. Psychosom Med. 2023 Jul-Aug 01;85(6):488-497.
Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk.
Mezue K, Osborne MT, Abohashem S, Zureigat H, Gharios C, Grewal SS, Radfar A, Cardeiro A, Abbasi T, Choi KW, Fayad ZA, Smoller JW, Rosovsky R, Shin L, Pitman R, Tawakol A. J Am Coll Cardiol. 2023 Jun 20;81(24):2315-2325.
Probable PTSD, PTSD symptom severity, and comorbid PTSD and hazardous drinking among sexual minority women compared to heterosexual women: A meta-analysis.
Scheer JR, Helminen EC, Cascalheira CJ, Jaipuriyar V, Shaw TJ, Zabelski S, Behari K, Pirog S, Batchelder AW, Possemato K, Hughes TL, Sullivan TP. Clin Psychol Rev. 2023 Jun;102:102283.
Sex and gender considerations in dementia: a call for global research.
Vila-Castelar C, Udeh-Momoh C, Aggarwal NT, Mielke MM. Nat Aging. 2023 May;3(5):463-465.
Suicidal thinking as affect regulation.
Coppersmith DDL, Millgram Y, Kleiman EM, Fortgang RG, Millner AJ, Frumkin MR, Bentley KH, Nock MK. J Psychopathol Clin Sci. 2023 May;132(4):385-395.
Preliminary feasibility of integrating tobacco treatment into SUD peer recovery coaching: a mixed-methods study of peer recovery coaches.
Streck JM, Regan S, Werner M, Glynn A, Villanti AC, Park ER, Wakeman SE, Evins AE, Rigotti NA. Addict Sci Clin Pract. 2023 Apr 30;18(1):25.
Positive psychological well-being: A novel concept for improving symptoms, quality of life, and health behaviors in irritable bowel syndrome.
Madva EN, Harnedy LE, Longley RM, Rojas Amaris A, Castillo C, Bomm MD, Burton Murray H, Staller K, Kuo B, Keefer L, Huffman JC, Celano CM. Neurogastroenterol Motil. 2023 Apr;35(4):e14531.
Returning integrated genomic risk and clinical recommendations: The eMERGE study.
Linder JE, Allworth A, Bland HT, Caraballo PJ, Chisholm RL, Clayton EW, Crosslin DR, Dikilitas O, DiVietro A, Esplin ED, Forman S, Freimuth RR, Gordon AS, Green R, Harden MV, Holm IA, Jarvik GP, Karlson EW, Labrecque S, Lennon NJ, Limdi NA, Mittendorf KF, Murphy SN, Orlando L, Prows CA, Rasmussen LV, Rasmussen-Torvik L, Rowley R, Sawicki KT, Schmidlen T, Terek S, Veenstra D, Velez Edwards DR, Absher D, Abul-Husn NS, Alsip J, Bangash H, Beasley M, Below JE, Berner ES, Booth J, Chung WK, Cimino JJ, Connolly J, Davis P, Devine B, Fullerton SM, Guiducci C, Habrat ML, Hain H, Hakonarson H, Harr M, Haverfield E, Hernandez V, Hoell C, Horike-Pyne M, Hripcsak G, Irvin MR, Kachulis C, Karavite D, Kenny EE, Khan A, Kiryluk K, Korf B, Kottyan L, Kullo IJ, Larkin K, Liu C, Malolepsza E, Manolio TA, May T, McNally EM, Mentch F, Miller A, Mooney SD, Murali P, Mutai B, Muthu N, Namjou B, Perez EF, Puckelwartz MJ, Rakhra-Burris T, Roden DM, Rosenthal EA, Saadatagah S, Sabatello M, Schaid DJ, Schultz B, Seabolt L, Shaibi GQ, Sharp RR, Shirts B, Smith ME, Smoller JW, Sterling R, Suckiel SA, Thayer J, Tiwari HK, Trinidad SB, Walunas T, Wei WQ, Wells QS, Weng C, Wiesner GL, Wiley K; eMERGE Consortium… Genet Med. 2023 Apr;25(4):100006.
A randomized controlled trial of varenicline and brief behavioral counseling delivered by lay counselors for adolescent vaping cessation: Study protocol.
Schuster RM, Cather C, Pachas GN, Nielsen L, Iroegbulem V, Dufour J, Potter K, Levy S, Gray KM, Evins AE. Front Psychiatry. 2023 Mar 15;14:1083791.
Repetitive Thoughts and Behaviors in Autism Spectrum Disorder: A Symptom-Based Framework for Novel Therapeutics.
Thom RP, McDougle CJ. ACS Chem Neurosci. 2023 Mar 15;14(6):1007-1016.
Positive psychological well-being and clinical characteristics in IBS: A systematic review.
Madva EN, Sadlonova M, Harnedy LE, Longley RM, Amonoo HL, Feig EH, Millstein RA, Zambrano J, Rojas Amaris A, Jurayj J, Burton Murray H, Staller K, Kuo B, Keefer L, Huffman JC, Celano CM. Gen Hosp Psychiatry. 2023 Mar-Apr;81:1-14.
Socioeconomic changes predict genome-wide DNA methylation in childhood.
Liu J, Cerutti J, Lussier AA, Zhu Y, Smith BJ, Smith ADAC, Dunn EC. Hum Mol Genet. 2023 Feb 19;32(5):709-719.
Virtual mentalizing imagery therapy for Spanish language Latino family dementia caregivers: A feasibility and acceptability study.
Ramirez-Gomez L, Johnson JK, Ritchie C, Meyer AK, Tan E, Madarasmi S, Gutierrez-Ramirez P, Aldarondo-Hernández C, Mischoulon D, Banerjee S, Jain FA. Front Psychol. 2023 Feb 16;14:961835.
Psychiatric comorbidities among adult patients with disorders of gut-brain interaction: Prevalence and relationships to treatment outcomes.
Madva EN, Staller K, Huffman JC, Kuo B, Garcia-Fischer I, Atkins M, Keefer L, Celano CM, Murray HB. Neurogastroenterol Motil. 2023 Feb;35(2):e14493.
Qualitative study of Oncology Clinicians’ Perceptions of Barriers to Offering Clinical Trials to Underserved Populations.
Perez GK, Oberoi AR, Finkelstein-Fox L, Park ER, Nipp RD, Moy B. Cancer Control. 2023 Jan-Dec;30:10732748231187829.
Unrecognized Functional Dyspepsia Among Those With Refractory Chronic Constipation: Analysis of a Tertiary Cohort.
Boyd T, Paz M, Ahmad I, Rao F, Samad A, Garcia-Fischer I, Silvernale C, Murray HB, Staller K. Gastro Hep Adv. 2023;2(4):573-579.
