New Publications from the Mass General Department of Psychiatry – April 11, 2025

The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs.  Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness. 

These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.

The association between pre-pregnancy and first-trimester hair cortisol and preterm birth: a causal inference model.

Chen Y, Künzel RG, Sanchez SE, Rondon MB, Pinto NI, Sanchez E, Kirschbaum C, Valeri L, Koenen KC, Gelaye B.  Eur J Epidemiol. 2024 Dec;39(12):1391-1400.

Perspectives on Integrating Biological Assessments to Address the Health Effects of Childhood Adversities.

Blevins EJ, Slopen N, Koenen KC, Mikesell C, Basu A.  Harv Rev Psychiatry. 2024 Dec 2. 

The phenomenology of postpartum psychosis: preliminary findings from the Massachusetts General Hospital Postpartum Psychosis Project.

Cohen LS, Arakelian M, Church TR, Dunk MM, Gaw ML, Yoon HE, Kobylski LA, Vanderkruik R, Freeman MP.  Mol Psychiatry. 2024 Dec 6. 

A Web-Based Mind-Body Intervention to Improve Resilience Among Patients With Nontraumatic Painful Upper-Extremity Conditions and Comorbid Risky Substance Use: Protocol for a Mixed Methods Study.

Levey N, Chen N, Ditre J, Sylvia L, Mudgal C, Bhashyam A, Garg R, Ring D, Vranceanu AM, Bakhshaie J.  JMIR Res Protoc. 2024 Dec 9;13:e64547. 

Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis.

Green JE, Wrobel A, Todd E, Marx W, Berk M, Lotfaliany M, Castle D, Cryan JF, Athan E, Hair C, Nierenberg AA, Jacka FN, Dawson S.  Br J Psychiatry. 2024 Dec 11:1-13. 

Sociodemographics and clinical factors associated with depression treatment outcomes in 65,741 first-time users of selective serotonin reuptake inhibitors: A Danish cohort study in older adults.

Ishtiak-Ahmed K, Christensen KS, Mortensen EL, Nierenberg AA, Gasse C.  J Affect Disord. 2024 Dec 15;367:244-254. 

Predictors of Outcome in Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder.

Palmer LP, Kambanis PE, Stern CM, Rossman SM, Mancuso CJ, Andrea AM, Burton-Murray H, Becker KR, Breithaupt L, Freid C, Asanza E, Lawson EA, Eddy KT, Thomas JJ.  Int J Eat Disord. 2024 Dec 16. 

A US-Based Consensus on Diagnostic Overlap and Distinction for Pediatric Feeding Disorder and Avoidant/Restrictive Food Intake Disorder.

Estrem HH, Pederson JL, Dodrill P, Romeo C, Thompson K, Thomas JJ, Zucker N, Noel R, Zickgraf H, Menzel J, Lukens CT, Goday PS, MacLaughlin S, Sharp WG.  Int J Eat Disord. 2024 Dec 16. 

Gut-derived appetite regulating hormones across the anorexia nervosa spectrum.

Muhammed M, Burton-Murray H, Plessow F, Becker KR, Breithaupt L, Lauze M, Slattery M, Lee H, Thomas JJ, Eddy KT, Lawson EA, Misra M.  Psychoneuroendocrinology. 2024 Dec 16;172:107257. 

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.

Katrinli S, Wani AH, Maihofer AX, Ratanatharathorn A, Daskalakis NP, Montalvo-Ortiz J, Núñez-Ríos DL, Zannas AS, Zhao X, Aiello AE, Ashley-Koch AE, Avetyan D, Baker DG, Beckham JC, Boks MP, Brick LA, Bromet E, Champagne FA, Chen CY, Dalvie S, Dennis MF, Fatumo S, Fortier C, Galea S, Garrett ME, Geuze E, Grant G, Hauser MA, Hayes JP, Hemmings SMJ, Huber BR, Jajoo A, Jansen S, Kessler RC, Kimbrel NA, King AP, Kleinman JE, Koen N, Koenen KC, Kuan PF, Liberzon I, Linnstaedt SD, Lori A, Luft BJ, Luykx JJ, Marx CE, McLean SA, Mehta D, Milberg W, Miller MW, Mufford MS, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff CB, Nugent NR, Orcutt HK, Qin XJ, Rauch SAM, Ressler KJ, Risbrough VB, Rutembesa E, Rutten BPF, Seedat S, Stein DJ, Stein MB, Toikumo S, Ursano RJ, Uwineza A, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Young RM, Zhao Y, van den Heuvel LL; PGC-PTSD Epigenetics Workgroup; PsychENCODE PTSD Brainomics Project; Traumatic Stress Brain Research Group; Uddin M, Nievergelt CM, Smith AK, Logue MW.  Genome Med. 2024 Dec 18;16(1):147. 

Psychedelic Therapeutics for Adolescents: Ethics, Safety, Opportunities, and Equipoise.

Dotson S, Luccarelli J.  J Am Acad Child Adolesc Psychiatry. 2024 Dec 19:S0890-8567(24)02060-4. 

Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance.

Großbach A, Suderman MJ, Hüls A, Lussier AA, Smith ADAC, Walton E, Dunn EC, Simpkin AJ.  Clin Epigenetics. 2024 Dec 20;16(1):187. 

Fluctuating Impairment and Complex Presentations: Evolving Care and Research Priorities in ADHD.

Surman C, Wilens T.  J Clin Psychiatry. 2024 Dec 23;86(1):24com15705. 

Comorbid Bipolar Disorder and Posttraumatic Stress Disorder: Clinical Implications and Management.

Chopra A, Matta SE, Vyas CM, Cohen JN, Temes CM, Ghaznavi S, Stern TA.  Prim Care Companion CNS Disord. 2024 Dec 24;26(6):24f03768. 

Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.

Morley TJ, Willimitis D, Ripperger M, Lee H, Zhou Y, Han L, Kang J, Meyerson WU, Smoller JW, Choi KW, Walsh CG, Ruderfer DM.  Genet Med. 2024 Dec 26:101353. 

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.

Cai N, Verhulst B, Andreassen OA, Buitelaar J, Edenberg HJ, Hettema JM, Gandal M, Grotzinger A, Jonas K, Lee P, Mallard TT, Mattheisen M, Neale MC, Nurnberger JI Jr, Peyrot WJ, Tucker-Drob EM, Smoller JW, Kendler KS.  Mol Psychiatry. 2024 Dec 27. 

The theoretical sensitivity of virtual assessment of catatonia.

Luccarelli J, Smith JR, Heckers S, Fricchione G, Wilson JE.  Schizophr Res. 2024 Dec;274:486-488. 

A qualitative exploration of the client-provider relationship and its role in discussing sexual health and HIV among African American women in the US South.

Vanderkruik R, Goodman GR, Blyler A, Ott C, Rivas A, Elopre L, Krakower D, Kudroff K, Wise J, Underwood E, McDonald V, Campbell M, Kempf MC, Psaros C.  Sex Reprod Healthc. 2024 Dec;42:101043. 

Heart rate variability wrist-wearable biomarkers identify adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.

Guichard L, An X, Neylan TC, Clifford GD, Li Q, Ji Y, Macchio L, Baker J, Beaudoin FL, Jovanovic T, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Gentile NT, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O’Neil BJ, Sergot P, Sanchez LD, Bruce SE, Sheridan JF, Harte SE, Ressler KJ, Koenen KC, Kessler RC, McLean SA; AURORA Study Group.  Psychiatry Res. 2024 Dec;342:116260.