Adding repetitive transcranial magnetic stimulation was shown to be more effective than switching antidepressants or augmenting with aripiprazole in patients with treatment-resistant depression.

Benzodiazepine use did not impact treatment response; however, in patients on higher benzodiazepine dosage, ketamine may be less effective at first.

Adjunctive testosterone was no more effective than placebo in improving symptoms of depression, fatigue, or sexual dysfunction in women with antidepressant-resistant MDD.

For decades medications used for the treatment of depression have targeted monoamine neurotransmitter systems (serotonin, norepinephrine, and dopamine); however, more recent research has focused on […]