New Publications from the Mass General Department of Psychiatry – July 12, 2024

The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs.  Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness. 

These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.

APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease.

Quiroz YT, Aguillon D, Aguirre-Acevedo DC, Vasquez D, Zuluaga Y, Baena AY, Madrigal L, Hincapié L, Sanchez JS, Langella S, Posada-Duque R, Littau JL, Villalba-Moreno ND, Vila-Castelar C, Ramirez Gomez L, Garcia G, Kaplan E, Rassi Vargas S, Ossa JA, Valderrama-Carmona P, Perez-Corredor P, Krasemann S, Glatzel M, Kosik KS, Johnson K, Sperling RA, Reiman EM, Sepulveda-Falla D, Lopera F, Arboleda-Velasquez JF.  N Engl J Med. 2024 Jun 20;390(23):2156-2164. 

Intimate Partner Violence-Related Brain Injury: Unmasking and Addressing the Gaps.

Esopenko C, Jain D, Adhikari SP, Dams-O’Connor K, Ellis M, Haag HL, Hovenden ES, Keleher F, Koerte IK, Lindsey HM, Marshall AD, Mason K, McNally JS, Menefee DS, Merkley TL, Read EN, Rojcyk P, Shultz SR, Sun M, Toccalino D, Valera EM, van Donkelaar P, Wellington C, Wilde EA.  J Neurotrauma. 2024 Apr 5.

Social networks of people with serious mental illness who smoke: potential role in a smoking cessation intervention.

Meza BPL, Pollack CE, Tilchin C, Jennings JM, Latkin CA, Cather C, Dickerson F, Evins AE, Wang NY, Daumit GL, Yuan C, Gudzune KA.  J Ment Health. 2024 Apr 8:1-10. 

Avoidant/restrictive food intake disorder symptoms are not as frequent as other eating disorder symptoms when ulcerative colitis is in remission.

Burton-Murray H, Kiser K, Gurung J, Williams K, Thomas JJ, Khalili H.  J Crohns Colitis. 2024 Apr 18:jjae052. 

Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study.

Schmidt ME, Kezic I, Popova V, Melkote R, Van Der Ark P, Pemberton DJ, Mareels G, Canuso CM, Fava M, Drevets WC.  Neuropsychopharmacology. 2024 Apr 22. 

A Four Country Study of Strangulation-related Alterations in Consciousness in Women who have Experienced Intimate Partner Violence: Co-occurrence with Traumatic Brain Injuries and Measures of Psychological Distress.

Adhikari SP, Daugherty JC, Quiroz Molinares N, Maldonado-Rodriguez N, Wallace C, Smirl J, Perez García M, De Los Reyes CJ, Hidalgo-Ruzzante N, van Donkelaar P, Valera E.  J Neurotrauma. 2024 Apr 26. 

Decreased Anogenital Gonorrhea and Chlamydia in Transgender and Gender Diverse Primary Care Patients Receiving Gender-Affirming Hormone Therapy.

Reisner SL, Deutsch MB, Mayer KH, Pletta DR, Campbell J, Potter J, Keuroghlian AS, Hughto JMW, Asquith A, Pardee DJ, Harris A, Quint M, Grasso C, Gonzalez A, Radix A.  J Gen Intern Med. 2024 May;39(7):1164-1172. 

Prescription Stimulant Use During Pregnancy and Risk of Neurodevelopmental Disorders in Children.

Suarez EA, Bateman BT, Hernandez-Diaz S, Straub L, McDougle CJ, Wisner KL, Gray KJ, Pennell PB, Lester B, Zhu Y, Mogun H, Huybrechts KF.  JAMA Psychiatry. 2024 May 1;81(5):477-488. 

Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation.

Abber SR, Buchanan KL, Clukey J, Joiner TE, Staller K, Burton-Murray H.  Neurogastroenterol Motil. 2024 May;36(5):e14773. 

Avoidant/restrictive food intake disorder prevalence is high in children with gastroparesis and functional dyspepsia.

Kaul I, Burton-Murray H, Musaad S, Mirabile Y, Czyzewski D, van Tilburg MAL, Sher AC, Chumpitazi BP, Shulman RJ.  Neurogastroenterol Motil. 2024 May;36(5):e14777. 

N -acetylcysteine for Trichotemnomania in an Adult Female With Williams Syndrome.

Carroll HM, McDougle CJ, Thom RP.  J Clin Psychopharmacol. 2024 May-Jun 01;44(3):321-323. 

From Consensus Statement to Pills to Pixels: New Innovations in Attention-Deficit/Hyperactivity Disorder Care.

Baweja R, Faraone SV, Childress AC, Weiss MD, Loo SK, Wilens TE, Waxmonsky JG.  J Child Adolesc Psychopharmacol. 2024 May;34(4):167-182. 

Depression – Understanding, Identifying, and Diagnosing.

Anderson E, Crawford CM, Fava M, Ingelfinger J, Nikayin S, Sanacora G, Scott-Vernaglia S, Teel J.  N Engl J Med. 2024 May 2;390(17):e41. D

Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task.

Dillon DG, Belleau EL, Origlio J, McKee M, Jahan A, Meyer A, Souther MK, Brunner D, Kuhn M, Ang YS, Cusin C, Fava M, Pizzagalli DA.  Comput Psychiatr. 2024 May 3;8(1):46-69. 

Trajectory of ghrelin and PYY around a test meal in males and females with avoidant/restrictive food intake disorder versus healthy controls.

Rozzell-Voss KN, Becker KR, Tabri N, Dreier MJ, Wang SB, Kuhnle M, Gydus J, Burton-Murray H, Breithaupt L, Plessow F, Franko D, Hauser K, Asanza E, Misra M, Eddy KT, Holsen L, Micali N, Thomas JJ, Lawson EA.  Psychoneuroendocrinology. 2024 May 6;167:107063. 

Impact of repeated blast exposure on active-duty United States Special Operations Forces.

Gilmore N, Tseng CJ, Maffei C, Tromly SL, Deary KB, McKinney IR, Kelemen JN, Healy BC, Hu CG, Ramos-Llordén G, Masood M, Cali RJ, Guo J, Belanger HG, Yao EF, Baxter T, Fischl B, Foulkes AS, Polimeni JR, Rosen BR, Perl DP, Hooker JM, Zürcher NR, Huang SY, Kimberly WT, Greve DN, Mac Donald CL, Dams-O’Connor K, Bodien YG, Edlow BL.  Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2313568121. 

Generalized Periodic Discharges Associated With Catatonia and Delirium: A Case Series.

Luccarelli J, Smith JR, Fricchione G, Westover MB.  J Neuropsychiatry Clin Neurosci. 2024 May 9:appineuropsych20230174. 

Validation of an ICD-Code-Based Case Definition for Psychotic Illness Across Three Health Systems.

Deo AJ, Castro VM, Baker A, Carroll D, Gonzalez-Heydrich J, Henderson DC, Holt DJ, Hook K, Karmacharya R, Roffman JL, Madsen EM, Song E, Adams WG, Camacho L, Gasman S, Gibbs JS, Fortgang RG, Kennedy CJ, Lozinski G, Perez DC, Wilson M, Reis BY, Smoller JW.  Schizophr Bull. 2024 May 10:sbae064. 

Exploring the neural basis of non-invasive prehabilitation in brain tumour patients: An fMRI-based case report of language network plasticity.

Boccuni L, Roca-Ventura A, Buloz-Osorio E, Leno-Colorado D, Martín-Fernández J, Cabello-Toscano M, Perellón-Alfonso R, Pariente Zorrilla JC, Laredo C, Garrido C, Muñoz-Moreno E, Bargalló N, Villalba G, Martínez-Ricarte F, Trompetto C, Marinelli L, Sacchet MD, Bartrés-Faz D, Abellaneda-Pérez K, Pascual-Leone A, Tormos Muñoz JM.  Front Oncol. 2024 May 17;14:1390542. 

A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging.

Placzek MS, Wilton DK, Weïwer M, Manter MA, Reid SE, Meyer CJ, Campbell AJ, Bajrami B, Bigot A, Bricault S, Fayet A, Frouin A, Gergits F, Gupta M, Jiang W, Melanson M, Romano CD, Riley MM, Wang JM, Wey HY, Wagner FF, Stevens B, Hooker JM.  ACS Cent Sci. 2024 Apr 25;10(5):1105-1114. 

Emergence of the natural history of Myhre syndrome: 47 patients evaluated in the Massachusetts General Hospital Myhre Syndrome Clinic (2016-2023).

Lin AE, Scimone ER, Thom RP, Balaguru D, Kinane TB, Moschovis PP, Cohen MS, Tan W, Hague CD, Dannheim K, Levitsky LL, Lilly E, DiGiacomo DV, Masse KM, Kadzielski SM, Zar-Kessler CA, Ginns LC, Neumeyer AM, Colvin MK, Elder JS, Learn CP, Mou H, Weagle KM, Buch KA, Butler WE, Alhadid K, Musolino PL, Sultana S, Bandyopadhyay D, Rapalino O, Peacock ZS, Chou EL, Heidary G, Dorfman AT, Morris SA, Bergin JD, Rayment JH, Schimmenti LA, Lindsay ME; MGH Myhre Syndrome Study Group.  Am J Med Genet A. 2024 May 23:e63638.