New Publications from the Mass General Department of Psychiatry – June 14, 2024

The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs.  Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness. 

These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.

Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.

Daskalakis NP, Iatrou A, Chatzinakos C, Jajoo A, Snijders C, Wylie D, DiPietro CP, Tsatsani I, Chen CY, Pernia CD, Soliva-Estruch M, Arasappan D, Bharadwaj RA, Collado-Torres L, Wuchty S, Alvarez VE, Dammer EB, Deep-Soboslay A, Duong DM, Eagles N, Huber BR, Huuki L, Holstein VL, Logue MW, Lugenbühl JF, Maihofer AX, Miller MW, Nievergelt CM, Pertea G, Ross D, Sendi MSE, Sun BB, Tao R, Tooke J, Wolf EJ, Zeier Z; PTSD Working Group of Psychiatric Genomics Consortium**; Berretta S, Champagne FA, Hyde T, Seyfried NT, Shin JH, Weinberger DR, Nemeroff CB, Kleinman JE, Ressler KJ; PTSD Working Group of Psychiatric Genomics Consortium.  Science. 2024 May 24;384(6698):eadh3707. 

Barriers to understanding patients with schizophrenia: Narrative exchange and the challenge of dialogical distance

Jang YJ, Yassin W. Nat. Mental Health 2, 9–11 (2024).

Disentangling sex differences in PTSD risk factors

Haering S, Seligowski AV, Linnstaedt SD, et al. Nat. Mental Health 2, 605–615 (2024). 

Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.

Haering S, Seligowski AV, Linnstaedt SD, Michopoulos V, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Gentile NT, Hudak LA, Pascual JL, Seamon MJ, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O’Neil BJ, Sanchez LD, Bruce SE, Harte SE, McLean SA, Kessler RC, Koenen KC, Stevens JS, Powers A.  Psychol Med. 2024 May 22:1-11. 

Pre-Pandemic Resilience to Trauma & COVID-19 Infection in Older Women.

Scoglio AAJ, Choi KW, Nishimi K, Sampson L, Koenen K, Roberts AL, Jha S, Kubzansky LD.  Psychosom Med. 2024 May 17. 

Depression – Treatment Options and Managing Depression in Primary Care.

Anderson E, Crawford CM, Fava M, Ingelfinger J, Sanacora G, Scott-Vernaglia S, Teel J.  N Engl J Med. 2024 May 16;390(19):e44. 

Measures of Suicidal Thoughts and Behaviors in Children and Adolescents: A Systematic Review and Recommendations for Use in Clinical and Research Settings.

Liu RT, Bettis AH, Lawrence HR, Walsh RFL, Sheehan AE, Pollak OH, Stephenson AR, Kautz MM, Marlowe RM.  Assessment. 2024 May 14:10731911241249438. 

Effect of Time From Onset of Major Depressive Disorder on the Therapeutic Response to Esmethadone (REL-1017).

Guidetti C, De Martin S, Serra G, Apicella M, Pani L, Pappagallo M, Mattarei A, Folli F, Manfredi P, Fava M.  J Clin Psychiatry. 2024 May 13;85(2):22m14735. 

A Mind-Body Intervention to Improve Physical Activity for Patients with Chronic Hip-Related Pain: Protocol for a Mixed Methods Study.

Jochimsen KN, Archer KR, Pollini RA, Parker RA, Enkhtsetseg N, Jacobs CA, Vranceanu AM.  J Pers Med. 2024 May 9;14(5):499. 

Prior resilience to trauma & coping during the COVID-19 pandemic.

Scoglio AAJ, Nishimi K, Choi KW, Koenen KC, Sampson LA, Jha SC, Kubzansky LD.  PLoS One. 2024 May 7;19(5):e0297169. 

Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning.

Horwitz A, McCarthy K, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Domeier RM, Rathlev NK, Sergot P, Sanchez LD, Bruce SE, Joormann J, Harte SE, Koenen KC, McLean SA, Sen S.  J Anxiety Disord. 2024 May 5;104:102876. 

Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task.

Dillon DG, Belleau EL, Origlio J, McKee M, Jahan A, Meyer A, Souther MK, Brunner D, Kuhn M, Ang YS, Cusin C, Fava M, Pizzagalli DA.  Comput Psychiatr. 2024 May 3;8(1):46-69. 

Depression – Understanding, Identifying, and Diagnosing.

Anderson E, Crawford CM, Fava M, Ingelfinger J, Nikayin S, Sanacora G, Scott-Vernaglia S, Teel J.  N Engl J Med. 2024 May 2;390(17):e41.